Poster Presentation 25th Lorne Cancer Conference 2013

Cancer Drug Discovery: ACRF Drug Discovery Centre for Childhood Cancer (#111)

Greg M Arndt 1 , Tim Failes 1 , Murray Norris 1 , Michelle Haber 1
  1. Children's Cancer Institute Australia, Randwick, NSW, Australia
High-throughput and high-content screening of large chemical libraries is a proven way to identify novel small molecules that target and modulate disease-associated biological systems and phenotypes. The Australian Cancer Research Foundation (ACRF) Drug Discovery Centre for Childhood Cancer, located within Children’s Cancer Institute Australia (CCIA) at the Lowy Cancer Research Centre in Sydney, was established to provide the infrastructure and know-how for small molecule screening to the cancer research community. The Drug Discovery Centre has been in operation for two years and, in that time, has completed several large- and small-scale screening projects in childhood and adult cancer cell-based assays using diversity, known bioactive and targeted chemical compound libraries. The Centre operates on a subsidised fee-for-service basis and provides expertise and assistance in scaling assays for high-throughput and robotic screening, isolating chemical compounds that affect specific cancer cellular activities and providing researchers with small molecule hits to be used in further drug development or as biological tools. In this poster, we outline the core components of the Centre, including the screening assay formats, small molecule libraries, compound storage and management, automation equipment, and the integrated data management system. In addition, we summarise the different services available, the process for accessing the Centre, and costs associated with both small- and large-scale screening. Finally, we provide an update on new equipment for high content screening of small molecule collections, the expansion of chemical compound libraries and additional services being provided in 2013. It is the goal of this facility to provide the cancer research community with state-of-the-art technology for discovering new therapeutics and tools for better understanding cancer biology.