Thursday, 14th February
25th Lorne Cancer Conference 2013
Days
Thursday, 14th February
Friday, 15th February
Saturday, 16th February
Tracks
Invited Speaker
Lorne Cancer
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Speakers
Registration
12:00PM - 6:00PM
Thursday, 14th February
Mantra Lobby
Session 1: Plenary 1
1:55PM - 3:00PM
Thursday, 14th February
Novartis Lecture Theatre
Chair: David Huang
Hallmarks of Cancer: From concepts to cancer medicine
-
Douglas Hanahan
Afternoon Tea
3:00PM - 4:00PM
Thursday, 14th February
Exhibition Hall
Session 2: Sustaining proliferative signalling
4:00PM - 6:00PM
Thursday, 14th February
Novartis Lecture Theatre
Chairs: Ricky Johnstone & Arun Dharmarajan
BRAF and RAS signalling in melanoma: basic biology to clinical exploitation.
-
Richard Marais
Pathway convergent evolution is a major determinant of treatment response to mTOR inhibitors in kidney cancer
-
James J Hsieh
RNA polymerase I: A novel target for the treatment of cancer
-
Grant A McArthur
Investigating the cell-of-origin of lung cancer using sophisticated mouse models
-
Kate D Sutherland
Live Intravital FLIM-FRET Imaging Reveals Spatial Regulation of Src Activity in Response to Dasatinib Treatment in Mutant p53-driven Pancreatic Cancer.
-
Paul Timpson
Dinner
6:00PM - 7:30PM
Thursday, 14th February
Mantra Dining Room
Poster Session 1
7:30PM - 10:00PM
Thursday, 14th February
Exhibition Hall
Targeting glucose metabolism - a strategy for overcoming drug resistance in breast cancer
-
Santhi Achuthan
Coordinate methylation of the alkaline phosphatase gene family in colon cancer. Implications for understanding the manifestation of the CpG island methylator phenotype (CIMP)
-
Sheren J Al-Obaidi
Investigating the function of the novel nuclear protein Manp.
-
James Allen
Evaluation the Biological activity of a computationally
de novo
deign Peptide in Skin Cancer Cells in
vitro
-
Nahlah Almansour
Lmo2 induced precancerous stem cells (pre-CSCs) require Notch and IL-7 signalling pathways for survival.
-
Raed F Alserihi
UNCOUPLING THE p53-DEPENDENT AND INDEPENDENT CELL CYCLE CHECKPOINTS UPON INHIBITION OF POL I TRANSCRIPTION
-
Marcia Amalia
Cytotoxic effects of pineapple bromelain in gastrointestinal carcinoma cell lines
-
Afshin Amini
SR protein splicing factors regulate stem cell properties
-
Minna-Liisa Anko
Impact of overexpression of pro-survival proteins on the development and treatment of MLL-AF9 acute myeloid leukaemia
-
Natasha Anstee
Cancer Drug Discovery: ACRF Drug Discovery Centre for Childhood Cancer
-
Greg M Arndt
New implication for an old drug: minocycline as a potential candidate for the treatment of ovarian cancer-induced malignant ascites
-
Parvin Ataie Kachoie
The expression of Dicer and Drosha in lymph node metastases of triple negative breast cancer.
-
Kelly A Avery-Kiejda
Monepantel suppress ovarian cancer cell proliferation by arresting cell cycle at G1 and down regulating cycline A and E, Cdk 2 and 4
-
Farnaz Bahrami B.
Cyclin-dependent kinase inhibitor Dinaciclib (SCH 727965) induces apoptosis of MLL-AF9 murine tumour cells
-
Adele J Baker
Potential markers for metformin susceptibility in colorectal cancer
-
Alice C Barnett
Heterogeneity and plasticity in melanoma leads to treatment failure and increased invasiveness that can be blocked by targeting TSP-1 and/or SNAIL
-
Andreas Behren
The Transcription Factor Runx2 is Important for Luminal Differentiation in the Pregnant Mammary Gland
-
Sarah Best
An Exploration of the 11q13 Breast Cancer Susceptibility Locus Using 3C and 4C Chromatin Conformation Capture Technologies
-
Joshua Betts
Developing Polyomic Personalised Therapeutic Strategies for Pancreatic Cancer: Molecular Phenotyping for Treating “One Patient at a Time”.
-
Andrew V Biankin
Noxa and Puma are the main drivers of chemotherapy related apoptosis in MLL-AF9 AML
-
Rebecca A Bilardi
microRNA-223 TARGETS STATHMIN AND REGULATES CELL MIGRATION IN MALIGNANT MESOTHELIOMA
-
Kimberly A Birnie
Delineating the tumor suppressive role of Scribble in prostate cancer metastasis
-
Yvonne C Borsetti
Investigating the effect of assay variation in determining whether melanoma follows a CD271-based cancer stem cell model.
-
Samantha E Boyle
Deregulated gp130/Stat3-Driven inflammation in lung cancer development
-
Gavin Brooks
The Transcriptome of Glioblastoma Stem Cells.
-
Daniel V Brown
Recruitment of human telomerase to telomeres
-
Tracy M Bryan
The contribution of stromal caveolin-1 to breast cancer metastasis.
-
Allan D Burrows
Continuous Treatment With Low Concentrations of the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells
-
Jason Cain
Hedgehog Signaling Maintains a Primitive Osteoblast Phenotype in Osteosarcoma
-
Jason Cain
Designing molecular biomarkers of therapeutic response to CX-5461, a first-in-class RNA Polymerase I inhibitor, for an upcoming Phase I clinical trial
-
Don P Cameron
The p53 isoform, Δ133p53 binds to and inhibits the p53 family members, p63 and p73.
-
Hamish G Campbell
SLIRP, a nuclear receptor corepressor, is a tumor suppressor in CRC that regulates cross-talk between the retinoic acid and notch signaling pathways
-
Patrick A Candy
Genome wide RNAi screen to identify regulators of the oncoprotein LMO4
-
Bianca D Capaldo
The FAcilitates Chromatin Transcription (FACT) protein complex promotes neuroblastoma tumour initiation
-
Daniel R Carter
Mechanisms underlying prostate cancer cell death induced by combinatorial treatment with an HDAC inhibitor and an antiandrogen
-
Sarah Carter
Increasing intracellular bioavailable copper destroys prostate cancer
-
Michael A Cater
An
in vitro
model of breast cancer dormancy for use in therapy discovery
-
Anannya Chakrabarti
Defining the involvement of the E6AP-PML axis in human prostate cancer.
-
Ai-Leen Chan
LRH-1 regulates hnRNPA1 and A2/B1 expression to modulate proliferation in breast cancer cells
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Ashwini Chand
Tumour immune infiltrate links tumour metastatic behavior and systemic Neutrophil-Lymphocyte Ratio (NLR) in colorectal cancer patients
-
Kellie A Charles
DNA methylation patterns in pediatric Acute Lymphoblastic Leukemia
-
Zac Chatterton
THE UBIQUITIN LIGASE SIAH IS A NOVEL REGULATOR OF EPITHELIAL-MESENCHYMAL TRANSITION IN BREAST CANCER
-
Anna Chen
HIGH TRIM16 EXPRESSION PREDICTS FAVOURABLE OUTCOME IN PATIENTS WITH METASTATIC MELANOMA
-
Belamy Cheung
INCREASING THE EFFECTIVENESS OF RETINOID ANTICANCER THERAPY FOR NEUROBLASTOMA
-
Belamy Cheung
Diagnostic Serum Biomarkers for Canine Hemangiosarcoma: a Potential Model of Human Angiosarcoma
-
Eunju Choi
Apoptotic sensitivity of tumour cells to HDACi is determined by sustained induction of the immediate-early genes Jun and Atf3.
-
Anderly C Chueh
Characterisation of a novel regulator of Hedgehog signalling, which regulates medulloblastoma tumour growth.
-
Sarah E Conduit
Differentiation and function of Foxp3
+
effector regulatory T cells.
-
Erika Cretney
Deletion of Myb in keratin 14 expressing cells delays mammary cancer onset
-
Ryan Cross
Whole exome sequence analysis of an
in vitro
model of drug-resistant T-cell acute lymphoblastic leukaemia
-
Mark N Cruickshank
Parity (childbearing) reduces the numbers of the MaSC-enriched CD24
+
CD49f
hi
cells.
-
Genevieve Dall
Oncogenic properties of cAMP Response Element Binding (CREB) protein in brain tumour cells
-
Paul Daniel
Functional analysis of genes in regions commonly amplified in high-grade serous and endometrioid ovarian cancer
-
Sally J Davis
A novel DNA damage-induced apoptotic pathway cooperates with p53 to enforce tumour suppression
-
Alex RD Delbridge
Determining the Role of Tropomyosins in Actin-Mediated Apoptosis
-
Melissa Desouza
Cooperative killing of MYC-driven B-lymphoma cells by inhibitors of the PI3K/AKT/mTOR pathway and RNA Polymerase I transcription
-
Jennifer R Devlin
Characterisation of pro-invasive transcriptional programs regulated by the Fra-1 transcription factor
-
Jeannine Diesch
Reduced expression of HDAC3 contributes to the resistance against HDAC inhibitor, vorinostat (SAHA) in mature lymphoid malignancies
-
Jianmin (Diane) Ding
Mast Cells and Macrophages are Therapeutic Targets in Inflammation-Associated Gastric Cancer
-
Moritz Eissmann
HoxA9-mediated immortalisation of myeloid progenitors requires Bcl-2
-
Gabriela Brumatti
Osteogenic differentiation of mesenchymal stem cells by PEDF in alginate microbeads
-
Mina Elahy
A novel murine model of lung cancer that facilitates acceleration of K-Ras
G12D
driven tumourigensis
-
Imogen Elsum
TRAF2 regulates TNF related inflammation and cell death in keratinocytes.
-
Nima Etemadi
Development of Arginine Methyltransferase PRMT5 Inhibitors as Novel Agents for the Treatment of Cancers
-
Hendrik Falk
A Genome-wide screen for novel genes involved in sensitisation to Histone Deacetylase inhibitors
-
Katrina J Falkenberg
MDM4 IS A NOVEL THERAPEUTIC TARGET IN HUMAN MELANOMA
-
Clare Fedele
Differential effects of MUC1 expression in colon cancer cells.
-
Harvey R Fernandez
Inhibition of histone acetyltransferases contributes to the anti-cancer activity of the phenothiazines
-
Harvey R Fernandez
Glucocorticoids inhibit breast tumour cell migration but increase metastasis to the lung in a mouse model of breast cancer
-
Ebony R Fietz
Understanding stathmin’s role in neuroblastoma metastasis
-
Christopher Fife
Differential microRNA expression following transformation of embryonic liver progenitor cells as a model for the development of hepatocellular carcinoma
-
Megan Finch
Investigating the roles of Epstein-Barr virus in the pathogenesis of Burkitt lymphoma
-
Leah Fitzsimmons
Screening for neuroblastoma drugs selectively active in the bone marrow environment
-
Jamie I Fletcher
The pro-tumourigenic role of microglia in glioblastoma multiforme pathogenesis: influence of CypA and CD147 signalling.
-
Gurkiran Kaur Flora
Molecular profiling of Pheochromocytoma
-
Aidan Flynn
Imaging Beyond the Diffraction Limit
-
Peter Franklin
Determinants of acquired chemo-resistance in ovarian cancer
-
Sarah Ftouni
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer
-
David Gallego Ortega
Expression of each gene of the polyamine pathway is prognostic of outcome and is directly regulated by the MYCN oncogene in neuroblastoma
-
Laura Gamble
E6AP as a novel regulator of the ASPP family members
-
Cristina Gamell
Sensitivity to dichloroacetate is determined by PDK expression
-
Bevan P Gang
Dysregulation of the repressive H3K27 trimethylation mark in head and neck squamous cell carcinoma contributes to dysregulated squamous differentiation
-
Orla M Gannon
A PR55α-containing PP2A complex positively regulates Fra-1/c-Jun function in tumour cells
-
Omer Gilan
Axl drives the development of acquired resistance to tyrosine kinase inhibitor therapy in head and neck cancer
-
Keith M Giles
Role of pro‐survival BCL-2 family members in haematopoiesis and acute myeloid leukemia.
-
Stefan P Glaser
Co-Culturing Prostate Cancer Cells with Bone Stromal Cells:A Reciprocal Interaction
-
Tristan T Glover
The asymmetric cell division regulator GPSM2 controls mammary progenitor activity and breast cancer progression.
-
Nathan J Godde
Phylogenetic analysis of clonal evolution of acquired drug resistance in liposarcoma
-
David Goode
Mitochondrial-STAT3 supports K-Ras induced myeloproliferative disease
in vivo.
-
Daniel J Gough
Mitochondrial-STAT3 dependent regulation of glutathione synthesis is a tumour specific vulnerability
.
-
Daniel Gough
-
Stephanie Grabow
Mcl-1 sustains survival of Myc over-expressing pre-leukaemic B lymphoid cells in Eμ-myc transgenic mice
-
Stephanie Grabow
Glioblastoma-specific Domain IV mutations in the EGFR are able to covalently dimerise in response to ligand and the small molecule inhibitors gefitinib and erlotinib.
-
Sameer A Greenall
A double strike against leukaemia: Dual targeting of PI3K and Cdk9 rapidly and selectively induces apoptosis in human AML cells.
-
Mark Guthridge
Targeted deletion of ILK in tumour-initiating cells improves survival of mice with highly aggressive Hedgehog-driven medulloblastoma.
-
Gregory E Hannigan
Folic acid promotes tumour growth and STAT3 activation
-
Mariann Fagernaes Hansen*
Mitochondrial Mutations and Metabolic Profiling of Pancreatic Cancer
-
Rae-Anne Hardie
Combined targeted expression of the
Pik3ca
H1047R
and
Apc
mutations in the gastrointestinal tract causes invasive adenocarcinomas
-
Lauren M Hare
APPLICATION OF IMAGING TECHNOLOGIES IN THE PRECLINICAL DEVELOPMENT OF NOVEL ONCOLOGY AGENTS
-
Athena Hatzimihalis
Tumour manifestation is dictated by
PML
in a gender-specific manner in a mutant p53 cancer model
-
Sue Haupt
Yeast techniques for modelling drugs targeting Bcl-2 and caspase family members
-
Christine J Hawkins
E2F7 regulates sensitivity to the cytotoxic actions of anthracyclines in squamous cell carcinoma
-
Mehlika Hazar Rethinam
Association of
ABCA1
cholesterol transporter with poor outcome and aggressive phenotype in serous ovarian cancer.
-
Michelle Henderson
Mutation of Foxo binding elements in the
bim
promoter does not abrogate Bim dependent killing
-
Marco J Herold
Differential glycosylation of circulating proteins as diagnostic biomarkers for Barrett’s oesophagus and oesophageal adenocarcinoma
-
Michelle M Hill
Regulation of colorectal tumor-initiating cells by the tight junction protein claudin-2.
-
Fred Hollande
Cancer metastasis via the blood circulation promoted by novel proteolytic mechanisms
-
John D Hooper
Connective tissue growth factor is increased in pre-B acute lymphoblastic leukaemia and mediates leukaemia - stromal cell interactions
-
Meegan Howlett
Improving patient immune responses to monoclonal antibody therapies in epithelial cancer through changes in cellular trafficking and signaling pathways.
-
Lingbo Hu
Improving patient immune responses to monoclonal antibody therapies in epithelial cancer through changes in cellular trafficking
-
Lingbo Hu
TSP-1 expression in melanoma correlates with EMT and increased invasiveness
-
Christopher Hudson
HIGH-RESOLUTION MOLECULAR PROFILING OF PRE-INVASIVE EPITHELIAL OVARIAN TUMOURS
-
Sally M Hunter
Defining the Role of E3 Ubiquitin Ligase UBR5 in Cancer Through Substrate Identification
-
Mary Iconomou
PTRF/cavin-1 modulates exosome content and function
-
Kerry L Inder
Harnessing the tumour adaptive response to hypoxia to identify novel combinations of the vascular disrupting agent BNC105 with targeted therapeutics.
-
Daniel J Inglis
Interleukin-3 signalling responses in myeloid cells
-
Anissa Jabbour
The homeobox transcription factor Hhex regulates haematopoietic stem cell cycling and emergency haematopoiesis.
-
Jacob T Jackson
A crucial role for the homeobox transcription factor Hhex in lymphogenesis.
-
Jacob T Jackson
Investigating the effects of lymphoma mutations enhancing NFκB signalling
-
Yogesh Jeelall
Normal breast epithelial subpopulations exhibit different responses to radiation induced DNA damage
-
Rebecca L Johnston
Potential roles for thrombopoietin and platelets in lymphoma
-
Emma C Josefsson
A critical role for ID4 in mammary stem cells and triple negative breast cancer
-
Simon Junankar
Association of Myc oncogene family expression with patient outcome in ovarian and colorectal carcinomas
-
MoonSun Jung
The partially-assembled GM-CSF receptor hexameric complex mediates cell survival
-
Winnie LT Kan
Characterization of molecular features of MYC dependence and identification of a synthetic lethal interaction between MYC and CDK1 in human breast cancer cells
-
Jian Kang
B-CELL ACTIVATING FACTOR (BAFF) PROMOTES LYMPHOMAS BY UPREGULATING TELOMERASE ACTIVITY IN B LYMPHOCYTES
-
Indzi Katik
Inhibitors of Mitochondrial Apoptotic Pathway in Parapox virus
-
Livleen Kaur
Functional interactions between p53 and anti-apoptotic Mcl-1 in sustaining the survival and growth of Myc-driven lymphoma.
-
Gemma L Kelly
Breast Cancer in Pakistan, A review of current Situation.
-
Ammara Khalid
Runx oncoproteins regulate cell fate decisions leading to senescence or survival.
-
Anna Kilbey
Combined targeting of JAK2 and Bcl-2/Bcl-xL as a novel treatment strategy in JAK2-driven B-cell precursor Acute Lymphoblastic Leukemia (BCP-ALL)
-
Sang Kyu Kim
Effects of Novel HDAC Inhibitors on the Proliferation, Colony Formation and Radiosensitivity of Brain Metastatic Breast Cancer Cells
-
Soo Kim
Implications of Fc-engineering to a humanised anti-Le
y
antibody on Fc gamma receptor binding
-
Dylan T King
Identification of Caspase-2 Specificity and Substrates
-
Tanja Kitevska
The effect of netrin-1 on colorectal cancer cells and its malignant properties
-
Suhyoun Ko
DISCOVERY OF NOVEL TELOMERASE INHIBITORS AND BINDING MODE PREDICTION
-
Manju Latha Krishna Moorthy
Thrombospondin 4 is upregulated in breast cancer-associated stroma
-
Jamie R Kutasovic
A High Throughput Screening Platform for the Identification of Small Molecule Inhibitors of the Ubiquitin E3 Ligase E6AP
-
Kurt Lackovic
IAPs limit RIPK1-induced TNF biosynthesis
-
Najoua Lalaoui
Chronic stress enhances progression of acute lymphoblastic leukemia through beta-adrenergic signaling
-
Donald M Lamkin
Mixl1 expression in human leukemias and lymphomas
-
Katherine K Lange
Understanding the roles of exosomes during epithelial-mesenchymal transition
-
Anh VP. Le
Bcor
loss-of-function mutations cooperate with Myc to drive lymphomagenesis in Eμ-Myc lymphoma.
-
Marcus Lefebure
Discovery, Structure-Guided Design and Biological Validation of the First Potent and Selective Inhibitor of the Pro-Survival BCL-2 Family Member BCL-X
L
-
Guillaume Lessene
Receptor Tyrosine Kinases differ in their ability to confer resistance to Vemurafenib (PLX4032) treatment in BRAFV600E melanoma.
-
Frederic Li
Targeting of Hedgehog pathway via pharmacologic inhibition of Gli induces apoptosis and autophagy in malignant mesothelioma cells
-
Chuan Bian Lim
Sorting nexin 5 is a regulator of macropinocytosis in macrophages which also affects cell proliferation
-
Jet Phey Lim
Structural biology of Scribble protein
-
Krystle Lim
Identification of the determinants in CSK-Homologous Kinase (CHK) essential for its tumour suppressor function
-
Ya Chee Lim
Medical utilization and cost of liver cancer under National Health Insurance in Taiwan: a population-based cross-sectional study
-
Yi-Hsien Lin
Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor
-
Lisa M Lindqvist
Re-engaging the Pax5-dependent transcriptional program in B progenitor acute lymphoblastic leukemia causes tumour differentiation and clearance
-
Grace J. Liu
Small molecule inhibitors of ICMT as potential cancer therapeutics
-
Aaron M Lock
Risk Factors Affecting the Survival Rate in Patients with SymptomaticPericardial Effusion Underwent Surgical Intervention
-
Mojtaba Lotfalian
Conventional Forceps or Hot Biopsy: Comparative Study of Two Methods in Diagnosis of Endobronchial Lesions
-
Mojtaba Lotfalian
Effects of Protein Arginine Methyltransferase 5 Knockdown or Inhibition on Tumour Cell Growth
-
Kym Lowes
The characterisation of Adenomatous polyposis coli (APC) at the centrosome
-
Christina Lui
Mechanistic basis for loss of cellular differentiation in colon cancer
-
Ian Y Luk
DIFFERENTIAL EFFECTS OF STORE OPERATED CALCIUM ENTRY PROTEINS ON THE CALCIUM-MEDIATED TRANSCRIPTION FACTORS NFκB AND NFAT IN MDA-MB-231 BREAST CANCER CELLS
-
Nicole A Luk
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